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KMID : 1137820170380050248
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의공학회지
2017 Volume.38 No. 5 p.248 ~ p.255
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Characteristics of PU/PEG Hybrid Scaffolds Prepared by Electrospinning
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Seol Bo-Kyung
Shin Ji-Yeon
Oh Ga-Yeon
Lee Deuk-Yong
Lee Myung-Hyun
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Abstract
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Polyurethane/polyethylene glycol(PU/PEG) hybrid scaffolds with various concentrations of PEG (0 to50wt%) were prepared by electrospinning to evaluate the mechanical properties and the biocompatibility of the PU/PEG blend scaffolds. The 12wt% PU/PEG polymers were studied due to the absence of beads. The ultimate tensile strength of 12wt% PU was 8.2 ± 0.5 MPa. The strength increased to 9.2 ± 0.7 MPa when 10% PEG was added to PU. However, the dry and the wet strength of PU/PEG scaffolds began to decrease dramatically when the PEG content was more than 10wt%. No cytotoxicity was observed for all the PU/PEG scaffolds investigated, indicating that the PU/PEG hybrid scaffolds are clinically safe and effective to small-diameter vascular grafts. In addition, the L-929 cells attached and proliferated well on the PU/PEG hybrid scaffolds.
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KEYWORD
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polyurethane , polyethylene glycol , scaffold , electrospinning , strength , cytotoxicity ,
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